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Title   진행성 및 재발성 대장암에서 5 - Fluorouracil 과 저용량 Leucovorin 병용 요법에 대한 제 2 상 임상 연구 ( 5 - Fluorouracil and Low dose Leucovorin in Advanced Colorectal Carcinoma )
Publicationinfo   1992 Jan; 024(05): 737-743.
Key_word   Advanced colorectal carcinoma, 5-Fluorourail, Leucovorin, Combination chemotherapy
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Abstract   We studied the therapeutic effect of 5-fluorouracil in combination with low dose leucovorin in patients with recurrent or metastatic carcinoma of the colan or rectum. 40 patients with clearly measurable lesions were entered into this study between Sep. 1989 to May 1991 and two were excluded from the analysis because one patient did not meet the eligibility criteria and the other was lost to follow-up. They were treated with leucovorin, 20 mg/m/day iv bolus, followed by 5-fluorouracil 370 mg/m/day iv bolus for 5 consecutive days. This regimen was re- peated every 4 weeks and 5-fluorouracil doses were escalated to 420 mg/m,day if the previous dose was tolerable. Male to female ratio was 25 to 13 with median age of S4 years(32-81 years). 22 patients had previous history of chemotherapy and 16 were previously untreated. There was no comPlete response and the partial response rate was 26.4%(10 of 3B patients). The median response duration was 5 months and the median time to progression was 3 months. Hematologic toxicities were mild and the rates of grade 3 or greater nonhematologic toxicity were 7.8%(3 of 38 patients). There was no treatment-related fatality. Our results indicate that the combination of -fluorouracil and leucovorin has modest activity for patients with metastatic or recurrent carcinoma of the rectum and colan.
저 자   윤성수(Sung Soo Yoon),임영혁(Young Hyuk Im),장정순(Joung Soon Jang),이재용(Jae Yong Lee)서창인(Chang In Suh),허대석(Dae Seog Heo),방영주(Yung Jue Bang),김노경(Noe Kyeong Kim)